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Index > Protein center > Gad2(Gene name) > Rat
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  • Gad2 (Gene name),
  • Glutamate decarboxylase 2 (Protein name ),  DCE2_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Gad2(Gad65);
    Protein name:
    Glutamate decarboxylase 2;
    Alternative:
    Glutamate decarboxylase 65 kDa isoform;65 kDa glutamic acid decarboxylase(GAD-65);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Catalyzes the production of GABA.
    Subcellular Location:
    Cytoplasm cytosol Cytoplasmic vesicle Cell junction synapse presynaptic cell membrane Lipid-anchor Golgi apparatus membrane Peripheral membrane protein Cytoplasmic side Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
    Protein Attributes:
    Sequence length:
    585
    Sequence:
    50:
    MASPGSGFWS | FGSEDGSGDP | ENPGTARAWC | QVAQKFTGGI | GNKLCALLYG | 
    100:
    DSEKPAESGG | SVTSRAATRK | VACTCDQKPC | SCPKGDVNYA | LLHATDLLPA | 
    150:
    CEGERPTLAF | LQDVMNILLQ | YVVKSFDRST | KVIDFHYPNE | LLQEYNWELA | 
    200:
    DQPQNLEEIL | THCQTTLKYA | IKTGHPRYFN | QLSTGLDMVG | LAADWLTSTA | 
    250:
    NTNMFTYEIA | PVFVLLEYVT | LKKMREIIGW | PGGSGDGIFS | PGGAISNMYA | 
    300:
    MLIARYKMFP | EVKEKGMAAV | PRLIAFTSEH | SHFSLKKGAA | ALGIGTDSVI | 
    350:
    LIKCDERGKM | IPSDLERRIL | EVKQKGFVPF | LVSATAGTTV | YGAFDPLLAV | 
    400:
    ADICKKYKIW | MHVDAAWGGG | LLMSRKHKWK | LNGVERANSV | TWNPHKMMGV | 
    450:
    PLQCSALLVR | EEGLMQSCNQ | MHASYLFQQD | KHYDLSYDTG | DKALQCGRHV | 
    500:
    DVFKLWLMWR | AKGTTGFEAH | IDKCLELAEY | LYNIIKNREG | YEMVFDGKPQ | 
    550:
    HTNVCFWFVP | PSLRVLEDNE | ERMSRLSKVA | PVIKARMMEY | GTTMVSYQPL | 
    585:
    GDKVNFFRMV | ISNPAATHQD | IDFLIEEIER | LGQDL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Glutamate decarboxylase 2
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    E0157m
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    96T
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    ELISA Kit for Rat Glutamate decarboxylase 2
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    E0157d
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    96T
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    ELISA Kit for Rat Glutamate decarboxylase 2
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    E0157h
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    ELISA Kit for Rat Glutamate decarboxylase 2
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    E0157p
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    96T
    ELISA Kit for Rat Glutamate decarboxylase 2
    Cat.:
    E0157r
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    Packing:
    96T
    CLIA Kit for Rat Glutamate decarboxylase 2
    Cat.:
    U0157d
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    Please sign in first.
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    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Glutamate decarboxylase 2
    Cat.:
    U0157h
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Glutamate decarboxylase 2
    Cat.:
    U0157m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Glutamate decarboxylase 2
    Cat.:
    U0157r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Glutamate decarboxylase 2
    Cat.:
    U0157p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Glutamate decarboxylase 2
    Polyclonal Antibody for Rat Glutamate decarboxylase 2
    Cat.:
    P0157Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Glutamate decarboxylase 2
    Polyclonal Antibody for Rat Glutamate decarboxylase 2
    Cat.:
    P0157Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Glutamate decarboxylase 2
    Cat.:
    P0157Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Glutamate decarboxylase 2
    Monoclonal Antibody for Rat Glutamate decarboxylase 2
    Monoclonal Antibody for Rat Glutamate decarboxylase 2
    Monoclonal Antibody for Rat Glutamate decarboxylase 2
    Monoclonal Antibody for Rat Glutamate decarboxylase 2
    Protein for Rat Glutamate decarboxylase 2
    Protein for Rat Glutamate decarboxylase 2
    Protein for Rat Glutamate decarboxylase 2
    Protein for Rat Glutamate decarboxylase 2
    Protein for Rat Glutamate decarboxylase 2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Two genes encode distinct glutamate decarboxylases."
      Erlander M.G. , Tillakaratne N.J. , Feldblum S. , Patel N. , Tobin A.J.
      Neuron7:91-100(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Hippocampus.
    2. 2.
      "Characterization of the proteins purified with monoclonal antibodies to glutamic acid decarboxylase."
      Chang Y.C. , Gottlieb D.I.
      J. Neurosci.8:2123-2130(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 190-219; 225-266 AND 524-558
      tissue: Brain.
    3. 3.
      "Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain."
      Christgau S. , Aanstoot H.-J. , Schierbeck H. , Begley K. , Tullin S. , Hejnaes K. , Baekkeskov S.
      J. Cell Biol.118:309-320(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PALMITOYLATION
    4. 4.
      "Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65."
      Shi Y. , Veit B. , Baekkeskov S.
      J. Cell Biol.124:927-934(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-30 AND CYS-45;MUTAGENESIS OF CYS-30; CYS-45; CYS-73; CYS-75; CYS-80; CYS-82 AND CYS-101
    5. 5.
      "Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha."
      Namchuk M. , Lindsay L. , Turck C.W. , Kanaani J. , Baekkeskov S.
      J. Biol. Chem.272:1548-1557(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-3; SER-6; SER-10 AND SER-13;BIOPHYSICOCHEMICAL PROPERTIES
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